NSAIDs and Cardiovascular Risk in Arthritis

Researchers found that use of nonsterodial anti-inflammatory drugs (NSAIDs) may raise blood pressure in patients with osteoarthritis. Patients with normal blood pressure at baseline developed hypertension when taking ibuprofen (23.2%) and naproxen (19.0%). Meanwhile, 10.3% of patients who took celecoxib developed hypertension.

Reference

Ruschitzka F, Borer JS, Krum H, et al. Differential blood pressure effects of ibuprofen, naproxen, and celecoxib in patients with arthritis: the PRECISION-ABPM (Prospective Randomized Evaluation of Celecoxib Integrated Safety Versus Ibuprofen or Naproxen Ambulatory Blood Pressure Measurement) trial. Eur Heart J. 2017;38(44):3282-3292.