Is Metabolic Syndrome Associated With Increased Risk of Mortality After PCI?

Patients with metabolic syndrome are not at significantly higher risk of in-hospital mortality after undergoing percutaneous coronary intervention (PCI) compared with the general population, according to study results presented at the National Lipid Association (NLA) Scientific Sessions, held in Atlanta, Georgia, between June 1 and June 4, 2023.

Metabolic syndrome has been associated with increased risk for cardiovascular disease. Researchers assessed whether patients with metabolic syndrome experienced higher rates of mortality, thrombosis, acute kidney injury, cardiogenic shock, cardiovascular accident, intraoperative and postoperative complications, ventricular tachycardia, and ventricular fibrillation after undergoing PCI compared with the general population.

Of the 432,764 patients who underwent PCI, 0.04% had a history of metabolic syndrome. At baseline, patients with a history of metabolic syndrome were younger compared with the general population (age, 61 years [95% CI, 60-62] vs 66 year [95% CI, 66-66]). When undergoing PCI, patients with a history of metabolic syndrome did not experience statistically significant higher rates of mortality (P =.7726), coronary artery thrombosis (P =.1309), acute kidney injury (P =.4399), cardiogenic shock (P =.3925), cardiovascular accident (P =.1443), intraoperative and postoperative complications (P =.1498), ventricular tachycardia (P =.7298), or ventricular fibrillation (P =.4869) compared with the general population.

While metabolic syndrome increases the risk for coronary artery disease, “there is no significant difference in in-hospital mortality between patients with metabolic syndrome and the general population who underwent PCI,” the study authors concluded.